Infertility is a widespread global health issue, affecting approximately 15% of couples worldwide. Among the various factors contributing to infertility, male infertility plays a significant role, accounting for nearly half of all cases. Asthenoteratozoospermia, a condition characterized by poor sperm motility and abnormal morphology, is one of the leading causes of male infertility and often results in reduced success in assisted reproductive technologies (ART), such as intracytoplasmic sperm injection (ICSI). In this context, L-carnitine, a naturally occurring compound with roles in mitochondrial bioenergetics and antioxidative defense, has emerged as a potential therapeutic intervention. This study explores the effectiveness of L-carnitine supplementation at various doses in improving sperm quality and ART outcomes in men with asthenoteratozoospermia, shedding light on its potential to enhance fertility and increase the success rates of ICSI procedures.