Protective effect of n-acetylcysteine in doxorubicin-induced primary ovarian failure in female rats

Overview

This study investigates the protective effects of N-acetylcysteine (NAC) in mitigating ovarian failure induced by doxorubicin (DOX), a chemotherapeutic agent known for its detrimental effects on female reproductive health. While chemotherapy provides life-saving cancer treatment, it often leads to severe reproductive toxicity, including damage to ovarian follicles and premature ovarian failure. This research explores NAC’s potential as a therapeutic agent by focusing on its antioxidant properties, which may counteract oxidative stress and inflammation, two primary mechanisms of DOX-induced ovarian damage. Through a series of histopathological, and biochemical, the study provides evidence that NAC preserves ovarian function and structure, offering a promising approach to protecting fertility in women undergoing chemotherapy.

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İlke Özer Aslan1,2, Mehmet Oz3, Huseyin Erdal4, İhsan Karaboğa5, Mehmet Doğan5

1Department of Obstetrics and Gynecology, Faculty of Medicine, Tekidağ Namık Kemal University, Tekirdağ, Türkiye

2Department of Obstetrics and Gynecology, In Vitro Fertilization and Reproductive Health Center, Acıbadem Maslak Hospital, İstanbul, Türkiye

3Department of Physiology, Faculty of Medicine, Aksaray University, Aksaray, Türkiye

4Department of Medical Genetics, Faculty of Medicine, Aksaray University, Aksaray, Türkiye

5Department of Histology and Embryology, Faculty of Medicine, Kırklareli University, Kırklareli, Türkiye

CORRESPONDENCE:

İlke Özer Aslan, ORCID ID: 0000-0002-3175-8354

E-mail: ilkeozeraslan@gmail.com

Co-authors’ information:

Mehmet Oz, ORCID ID: 0000-0003-4167-2623, E-mail: ozmhmt@gmail.com

Huseyin Erdal, ORCID ID: 0000-0003-0786-5077, E-mail: herdalyfa@gmail.com

İhsan Karaboğa, ORCID ID: 0000-0003-0786-5077, E-mail: ihsankaraboga@gmail.com

Mehmet Doğan, ORCID ID: 0000-0002-8497-1829, E-mail: doganmehmet@klu.edu.tr

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